Generalized Multi |
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Generalized Multi
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The standard linear-quadratic (LQ) model is currently the preferred model for describing the ionizing radiation-induced cell survival curves and tissue responses. And the LQ model is also widely used to calculate isoeffect doses for comparing different fractionated schemes in clinical radiotherapy. Despite its ubiquity, because the actual dose-response curve may appear linear at high doses in the semilogarithmic plot, the application of the LQ model is greatly challenged in the high-dose region, while the dose employed in stereotactic body radiotherapy (SBRT) is often in this area. Alternatively, the biophysical models of radiation-induced effects with a linear-quadratic-linear (LQL) characteristic can well fit the dose-survival curve of cells in vitro. However, most of these LQL models are phenomenological and have not fully considered the biophysical mechanism of radiation-induced damage and repair, and the fitting quality decreases in some high-dose ranges. In this work, to provide an alternative model to describe the cell survival curves in high-dose ranges and predict the biologically effective dose (BED) for SBRT, we propose a novel generalized multi-hit model with a closed-form solution by considering an upper bound on the number of lethal damages induced by radiation that can be repaired in a cell. This model has a clear biophysical basis and a simple expression, and also has the LQL characteristic under low- and high-dose approximate conditions. The experimental data fitting indicated that compared to the standard LQ model and our previously generalized target model, the current model can better fit the radiation-induced cell survival curves in the high-dose ranges (P 0.86, P
中文翻译：
目前，标准线性二次（LQ）模型是用于描述电离辐射诱导的细胞存活曲线和组织反应的首选模型。LQ模型也被广泛用于计算等效效应剂量，以比较临床放疗中的不同分级方案。尽管存在无处不在，因为在半对数图中高剂量时实际剂量-反应曲线可能呈线性，因此LQ模型的应用在高剂量区域受到很大挑战，而立体定向身体放疗（SBRT）的剂量通常在这个地区。或者，具有线性二次线性（LQL）特征的辐射诱发效应的生物物理模型可以很好地拟合体外细胞的剂量生存曲线。然而，这些LQL模型中的大多数都是现象学的，尚未完全考虑辐射诱发的损伤和修复的生物物理机制，并且在某些高剂量范围内拟合质量下降。在这项工作中，为了提供一种替代模型来描述高剂量范围内的细胞存活曲线并预测SBRT的生物学有效剂量（BED），我们通过考虑一种可以在细胞中修复的辐射引起的致死性损害数量的上限。该模型具有明确的生物物理基础和简单的表达，并且在低剂量和高剂量近似条件下也具有LQL特性。实验数据拟合表明，与标准LQ模型和我们之前的广义目标模型相比，当前模型可以更好地拟合大剂量范围内辐射诱导的细胞存活曲线（P 0.86，P |
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